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52nd ERA-EDTA Congress

 

28-31 May 2015 London
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Discussion forum - 52nd ERA-EDTA Congress
    Topic - L1) Dialysis. Extracorporeal dialysis: techniques and adequacy.

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Poster: 507
Visits: 137
Title: EFFECT OF DIALYSATE FLOW RATE (QD) ON SMALL AND MIDDLE MOLECULAR SOLUTE REMOVAL IN HIGH-EFFICIENCY ON-LINE HAEMODIAFILTRATION (OL-HDF)
Authors: Luciano A. Pedrini , Simona Zerbi, Angelo Castellano, Mauro Pezzotta.
Centre: Nefrologia e Dialisi - NephroCare - Bolognini Hospital - Seriate - Italy

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EFFECT OF DIALYSATE FLOW RATE (QD) ON SMALL AND MIDDLE MOLECULAR SOLUTE REMOVAL IN HIGH-EFFICIENCY ON-LINE HAEMODIAFILTRATION (OL-HDF)

Luciano A. Pedrini
Thread initiator
Subspeciality
Reg: 5/15/2015 3:20:00 PM
Comment# 1
The mass transfer-area coefficient for a given dialyzersolute combination (KoA) is assumed constant in hollow fiber dialyzers. However, controversial effects on KoA and solute clearance (K) were reported by increasing the dialysate flow rate (QD). Leypoldt 1,2 showed that urea KoA increases in vitro by an average of 147 (range 3 to 33) with an increase in QD from 500 to 800 ml/min, with greater effect for high flux membranes. While other Authors confirmed these findings in vivo3,4, Bihami5 reported that increasing QD beyond 600 ml/min have only a modest impact on dialyzer performance, limited to the theoretical increase predicted by the Michaels model6 for a constant KoA (Equation1).More recently it was claimed that reduced QD rates in high-efficiency on-line HDF offer substantial savings in dialysate consumption without decreasing dialysis efficiency with respect to high-flux haemodialysis7.

Comment added on 5/15/2015 3:20:00 PM 
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